European Test and Risk Assessment Strategies for Mixtures
Every day, we are exposed to a mixture of
multiple chemicals via food intake, inhalation and dermal contact.
The risk to health that may result from this depends on how the
effects of different chemicals in the mixture combine, and whether
there is any synergism or antagonism between them. The number of
different combinations of chemicals in mixtures is infinite and an
efficient test strategy for mixtures is lacking. EuroMix
will apply several in-silico and in-vitro tools to mixtures of
chemicals that can have an effect on four selected endpoints:
liver, hormones, development and immunology.
Furthermore, there is a societal need to reduce animal testing, which is the current practice in safety testing of chemicals.
The EuroMix project will deliver a mixture test strategy and test instruments using novel techniques as recently proposed by the Joint Research Centre (JRC) of the European Commission. The tests will result in data needed for refining future risk assessment of mixtures relevant to national food safety authorities, public health institutes, the European Food Safety Authority (EFSA), the European Chemical Agency (ECHA), industry, regulatory bodies and other stakeholders. Ultimately, this will provide information for future risk management decisions on the safety of chemicals in mixtures to be taken by the European Commission and the Codex Alimentarius.